Overcoming Poor Solubility of Dimenhydrinate: Development, Optimization and Evaluation of Fast Dissolving Oral Film

Purpose: To develop fast dissolving oral film to address vomiting and nausea in pediatric population.Methods: Oral films of Dimenhydrinate were prepared by solvent casting method by using hydroxypropylmethyl cellulose E5 (HPMC E5), polyethylene glycol 400 (PEG 400) and croscarmellose sodium.Solubility of dimenhydrinate was enhanced by ethanol as a

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News from around the RNA world: new avenues in RNA biology, biotechnology and therapeutics from the 2022 SIBBM meeting

Since the formalization of Luggage tags the Central Dogma of molecular biology, the relevance of RNA in modulating the flow of information from DNA to proteins has been clear.More recently, the discovery of a vast set of non-coding transcripts involved in crucial aspects of cellular biology has renewed the enthusiasm of the RNA community.Moreover,

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Real-Time Large-Scale Dense Mapping with Surfels

Real-time Pot Supports dense mapping systems have been developed since the birth of consumer RGB-D cameras.Currently, there are two commonly used models in dense mapping systems: truncated signed distance function (TSDF) and surfel.The state-of-the-art dense mapping systems usually work fine with small-sized regions.The generated dense surface may

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